DUSP10

Name

dual specificity phosphatase 10

Type

protein-coding

Position

221,700,666–221,743,169 (−)

Aliases

MKP-5, MKP5

Ensembl

ENSG00000143507

RefSeq RNA

NM_007207.6, NM_144728.2, NM_144729.2, NR_111939.2, NR_111940.2

RefSeq protein

NP_009138.1, XP_016855636.1, XP_047298898.1, XP_047298904.1, XP_054189977.1

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].

via MyGene.info

Wikidata facts

Instance of

gene

Image

Protein DUSP10 PDB 1zzw.png

via Wikidata · CC0