Dinorfinas
Sign in to saveAlso known as dynorphins
Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neoendorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal. Occasionally, prodynorphin is not fully processed, leading to the release of big dynorphin, a 32-amino acid molecule consisting of both dynorphin A and dynorphin B.
Key facts
- Protein.Name
- prodynorphin
- Protein.caption
- Dynorphin in the κ opioid receptor
- Protein.image
- 3D Dynorphin KOR.png
- Protein.HGNCid
- 8820
- Protein.Symbol
- PDYN
- Protein.EntrezGene
- 5173
- Protein.OMIM
- 131340
- Protein.RefSeq
- NM_024411
- Protein.UniProt
- P01213
- Protein.Chromosome
- 20
- Protein.Arm
- p
- Protein.Band
- ter
- Protein.LocusSupplementaryData
- -p12.2
via Wikipedia infobox
Research
5,234 papers- Dynorphin and its role in alcohol use disorder.Brain research · 2020
- Dynorphin 1-17 biotransformation peptides: properties, challenges and solutions for future therapeutics development.Future medicinal chemistry · 2023
- Dynorphin and epilepsy.Progress in neurobiology · 1996
- Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders.Brain research · 2019
- Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder.Journal of neurotrauma · 2022
via PubMed
Wikidata facts
- Subclass of
- pore-forming toxin
Show 2 more facts
- Commons category
- Dynorphins
- exact match
- www.tcdb.org/search/result.php?tc=1.C.89
via Wikidata · CC0
Article · Español
Las dinorfinas (del griego dynamis poder, potencia) son un subtipo de péptidos opiáceos derivados de la pro-dinorfina que actúan como neurotransmisores en el sistema nervioso central. Se trata de neurotransmisores peptídicas entre los cuales encontramos también otras sustancias como las endorfinas y las taquininas. Los opioides son sustancias que actúan en receptores específicos para producir efectos parecidos a los de la morfina. Estos receptores se encuentran principalmente en el sistema nervioso periférico y central y en el tracto gastrointestinal.
Abstract from DBpedia / Wikipedia · CC BY-SA