Dynorfine
Sign in to saveAlso known as dynorphins
Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neoendorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal. Occasionally, prodynorphin is not fully processed, leading to the release of big dynorphin, a 32-amino acid molecule consisting of both dynorphin A and dynorphin B.
Key facts
- Protein.Name
- prodynorphin
- Protein.caption
- Dynorphin in the κ opioid receptor
- Protein.image
- 3D Dynorphin KOR.png
- Protein.HGNCid
- 8820
- Protein.Symbol
- PDYN
- Protein.EntrezGene
- 5173
- Protein.OMIM
- 131340
- Protein.RefSeq
- NM_024411
- Protein.UniProt
- P01213
- Protein.Chromosome
- 20
- Protein.Arm
- p
- Protein.Band
- ter
- Protein.LocusSupplementaryData
- -p12.2
via Wikipedia infobox
Research
5,234 papers- Dynorphin and its role in alcohol use disorder.Brain research · 2020
- Dynorphin 1-17 biotransformation peptides: properties, challenges and solutions for future therapeutics development.Future medicinal chemistry · 2023
- Dynorphin and epilepsy.Progress in neurobiology · 1996
- Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders.Brain research · 2019
- Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder.Journal of neurotrauma · 2022
via PubMed
Wikidata facts
- Subclass of
- pore-forming toxin
Show 2 more facts
- Commons category
- Dynorphins
- exact match
- www.tcdb.org/search/result.php?tc=1.C.89
via Wikidata · CC0
Article · Nederlands
Dynorfines zijn opioïde peptides die werken als neurotransmitter. Ze worden geproduceerd door groepen zenuwcellen, op verschillende plekken in het centraal zenuwstelsel, zoals de hypothalamus, de hippocampus en het ruggenmerg. Voorbeelden van dynorfine zijn dynorfine A en dynorfine B. Dynorfine heeft veel verschillende functies, waaronder bijdragen aan het patroon van elektrische activiteit in de hersenen, het zorgen voor negatieve feedback, inhibitie (afremming) bij bepaalde processen en bij het controleren van het hongergevoel.
Abstract from DBpedia / Wikipedia · CC BY-SA