DYRK1A

Name

dual specificity tyrosine phosphorylation regulated kinase 1A

Type

protein-coding

Position

37,365,573–37,526,358 (+)

Aliases

DYRK, DYRK1, HP86, MNB, MNBH, MRD7

Ensembl

ENSG00000157540

RefSeq RNA

NM_001347721.2, NM_001347722.2, NM_001347723.2, NM_001396.5, NM_101395.2

RefSeq protein

NP_001334650.1, NP_001334651.1, NP_001334652.1, NP_001387.2, NP_567824.1

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

dual specificity tyrosine phosphorylation regulated kinase 1A

Symbol

DYRK1A

Biotype

Protein coding

Organism

Homo sapiens

Location

21:37,365,573-37,526,358

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein DYRK1A PDB 2VX3.png

via Wikidata · CC0