E2F3

Also known as E2F-3, E2F transcription factor 3

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.

Gene data

E2F3

Name: E2F transcription factor 3
Type: protein-coding
Position: 20,401,840–20,493,714 (+)
Aliases: E2F-3
Ensembl: ENSG00000112242
RefSeq RNA: NM_001243076.3, NM_001949.5, XM_005248865.6, XM_005248866.6, XM_011514324.4
RefSeq protein: NP_001230005.1, NP_001940.1, XP_005248922.1, XP_005248923.1, XP_011512626.1

This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].

Gene Ontology

Biological process

G1/S transition of mitotic cell cycle regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter protein import into nucleus positive regulation of transcription by RNA polymerase II negative regulation of fat cell proliferation

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleoplasm nucleoplasm nucleoplasm transcription regulator complex RNA polymerase II transcription regulator complex

Pathways

Cell cycle - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Cushing syndrome - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Hepatitis B - Homo sapiens (human)Human cytomegalovirus infection - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

E2F transcription factor 3

Symbol: E2F3
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:20,401,840-20,493,714
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

exact match: identifiers.org/ncbigene/1871
HomoloGene ID: 74413
found in taxon: Homo sapiens
genomic end: 20493714
genomic start: 20401879
chromosome: human chromosome 6
cytogenetic location: 6p22.3
expressed in: bone marrow

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Encyclopedic overview

6 sections

Contents

Function
Interactions
See also
References
Further reading
External links

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.

== Function ==

Excerpted from Wikipedia’s “E2F3” article, available under the CC BY-SA 4.0 licence.

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E2F3

Gene data

Gene Ontology

Pathways

Gene · Ensembl

Wikidata facts

Encyclopedic overview

Available in 5 languages

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