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GeneQ14864821· pop 7· linked from 862 articles

EGR1

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Also known as AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, early growth response 1

EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

Gene data

EGR1
Name
early growth response 1
Type
protein-coding
Position
138,465,190–138,471,204 (+)
Aliases
AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZIF268, ZNF225
Ensembl
ENSG00000120738
RefSeq RNA
NM_001964.3
RefSeq protein
NP_001955.1

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014].

Gene Ontology

Pathways

Apelin signaling pathway - Homo sapiens (human)GnRH signaling pathway - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)Prion disease - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)PIP3 activates AKT signalingPIP3 activates AKT signalingCytokine Signaling in Immune systemSignal Transduction

via MyGene.info

Gene · Ensembl

early growth response 1

Symbol
EGR1
Biotype
Protein coding
Organism
Homo sapiens
Location
5:138,465,190-138,471,204
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Zinc finger DNA complex.png
Show 8 more facts
HomoloGene ID
56394
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/1958
genomic end
138469303
genomic start
138465479
chromosome
human chromosome 5
cytogenetic location
5q31.2
expressed in
renal medulla
Sources (5)

via Wikidata · CC0

~4 min read

Encyclopedic overview

8 sections
Contents
  • Function
  • Structure
  • DNA binding specificity
  • Interactions
  • See also
  • References
  • Further reading
  • External links

EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

Excerpted from Wikipedia’s “EGR1” article, available under the CC BY-SA 4.0 licence.

Available in 7 languages

via Wikidata sitelinks · CC0