EIF2AK4
Sign in to saveAlso known as GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.
Gene data
EIF2AK4- Name
- eukaryotic translation initiation factor 2 alpha kinase 4
- Type
- protein-coding
- Position
- 39,934,062–40,036,656 (+)
- Aliases
- GCN2, PVOD2
- Ensembl
- ENSG00000128829
- RefSeq RNA
- NM_001013703.4
- RefSeq protein
- NP_001013725.2
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 2 alpha kinase 4
- Symbol
- EIF2AK4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:39,934,062-40,036,656
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- EIF2AK4.png
Show 8 more facts
- HomoloGene ID
- 40891
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/440275
- genomic end
- 40327797
- genomic start
- 39934115
- chromosome
- human chromosome 15
- cytogenetic location
- 15q15.1
- expressed in
- caudate nucleus
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]
Excerpted from Wikipedia’s “EIF2AK4” article, available under the CC BY-SA 4.0 licence.