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GeneQ18033196· pop 5· linked from 207 articles

EIF3D

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Also known as EIF3S7, eIF3-p66, eIF3-zeta, eukaryotic translation initiation factor 3 subunit D

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

Gene data

EIF3D
Name
eukaryotic translation initiation factor 3 subunit D
Type
protein-coding
Position
36,510,847–36,529,245 (−)
Aliases
EIF3S7, eIF3-p66, eIF3-zeta
Ensembl
ENSG00000100353
RefSeq RNA
NM_003753.4, NR_156418.2, XM_047441560.1, XM_054326077.1
RefSeq protein
NP_003744.1, XP_047297516.1, XP_054182052.1

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

RNA transport - Homo sapiens (human)Antimicrobial mechanism of IFN-stimulated genesCytokine Signaling in Immune systemL13a-mediated translational silencing of Ceruloplasmin expressionImmune SystemMetabolism of proteinsEukaryotic Translation InitiationTranslation initiation complex formationActivation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SFormation of a pool of free 40S subunits

via MyGene.info

Gene · Ensembl

eukaryotic translation initiation factor 3 subunit D

Symbol
EIF3D
Biotype
Protein coding
Organism
Homo sapiens
Location
22:36,510,847-36,529,245
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
2782
exact match
identifiers.org/ncbigene/8664
found in taxon
Homo sapiens
genomic end
36529184
genomic start
36510855
chromosome
human chromosome 22
cytogenetic location
22q12.3
expressed in
body of stomach
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • Interactions
  • See also
  • References
  • Further reading

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

== Function ==

Excerpted from Wikipedia’s “EIF3D” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0