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GeneQ18035420· pop 5· linked from 206 articles

EIF3M

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Also known as B5, PCID1, TANGO7, hfl-B5, GA17, eukaryotic translation initiation factor 3 subunit M

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.

Gene data

EIF3M
Name
eukaryotic translation initiation factor 3 subunit M
Type
protein-coding
Position
32,583,742–32,606,264 (+)
Aliases
B5, GA17, PCID1, TANGO7, hfl-B5
Ensembl
ENSG00000149100
RefSeq RNA
NM_001307929.2, NM_006360.6
RefSeq protein
NP_001294858.1, NP_006351.2

This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011].

Gene Ontology

Pathways

Antimicrobial mechanism of IFN-stimulated genesCytokine Signaling in Immune systemL13a-mediated translational silencing of Ceruloplasmin expressionImmune SystemMetabolism of proteinsEukaryotic Translation InitiationTranslation initiation complex formationActivation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SFormation of a pool of free 40S subunitsFormation of the ternary complex, and subsequently, the 43S complex

via MyGene.info

Gene · Ensembl

eukaryotic translation initiation factor 3 subunit M

Symbol
EIF3M
Biotype
Protein coding
Organism
Homo sapiens
Location
11:32,583,742-32,606,264
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections
Contents
  • See also
  • References
  • Further reading
  • External links

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.

HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV).

Excerpted from Wikipedia’s “EIF3M” article, available under the CC BY-SA 4.0 licence.

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