EIF4G1

Name

eukaryotic translation initiation factor 4 gamma 1

Type

protein-coding

Position

184,314,490–184,335,358 (+)

Aliases

EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18

Ensembl

ENSG00000114867

RefSeq RNA

NM_001194946.2, NM_001194947.2, NM_001291157.2, NM_004953.5, NM_182917.4

RefSeq protein

NP_001181875.2, NP_001181876.2, NP_001278086.2, NP_004944.3, NP_886553.3

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].

via MyGene.info

Gene · Ensembl

eukaryotic translation initiation factor 4 gamma 1

Symbol

EIF4G1

Biotype

Protein coding

Organism

Homo sapiens

Location

3:184,314,490-184,335,358

Strand

Forward (+)

Assembly

GRCh38