EIF4G2

Name

eukaryotic translation initiation factor 4 gamma 2

Type

protein-coding

Position

10,796,817–10,808,947 (−)

Aliases

AAG1, DAP5, NAT1, P97

Ensembl

ENSG00000110321

RefSeq RNA

NM_001042559.3, NM_001172705.1, NM_001418.4

RefSeq protein

NP_001036024.3, NP_001166176.1, NP_001409.3

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

eukaryotic translation initiation factor 4 gamma 2

Symbol

EIF4G2

Biotype

Protein coding

Organism

Homo sapiens

Location

11:10,796,817-10,808,947

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein EIF4G2 PDB 3D3M.png

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