Eldecalcitol
Sign in to saveEldecalcitol is an analog of calcitriol, the active form of vitamin D.
Chemical data
- Formula
- C30H50O5
- Molecular weight
- 490.7 g/mol
- IUPAC name
- (1R,2R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
via PubChem
Research
274 papers- Eldecalcitol for the treatment of osteoporosis.Clinical interventions in aging · 2013
- Eldecalcitol for sarcopenia prevention in adults with prediabetes.The lancet. Healthy longevity · 2024
- Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway.Drug design, development and therapy · 2020
- Eldecalcitol: a review of its use in the treatment of osteoporosis.Drugs · 2011
- Eldecalcitol replaces endogenous calcitriol but does not fully compensate for its action in vivo.The Journal of steroid biochemistry and molecular biology · 2014
via PubMed
Article
8 sectionsContents
- Discovery
- Effects
- Treatment for Osteoporosis
- Pharmacology
- Mechanism of Action
- Dosage
- Chemistry
- References
Eldecalcitol is an analog of calcitriol, the active form of vitamin D.
Commonly used in Japan for the treatment of osteoporosis. Osteoporosis is a common bone disease among the older generation, with an estimated prevalence of over 200 million people. This condition often results in bone fractures due to abnormally low bone mass density, and is a leading cause of disability, especially among developed countries with longer average life spans.