Structure via PubChem · Public domain (PubChem)
tacalcitol
Sign in to saveAlso known as 1α,24(OH)2D3, 1,24-dihydroxyvitamin D3, TV-02H
Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog. Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.
Chemical data
- Formula
- C27H44O3
- Molecular weight
- 416.6 g/mol
- IUPAC name
- trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
- SMILES
- C[C@H](CC[C@H](C(C)C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
- InChIKey
- BJYLYJCXYAMOFT-RSFVBTMBSA-N
- XLogP
- 5.3
- Polar surface area
- 60.7 Ų
- H-bond donors
- 3
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- psoriasis, psoriasis vulgaris
via ChEMBL · EBI
Wikidata facts
- Subclass of
- secosteroid
- Mass
- 416.329045
Show 5 more facts
- chemical formula
- C₂₇H₄₄O₃
- isomeric SMILES
- C[C@H](CC[C@H](C(C)C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
- canonical SMILES
- CC(C)C(CCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C)O
- medical condition treated
- psoriasis
- physically interacts with
- vitamin D receptor
Sources (8)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Mechanism
- Uses
- References
Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog. Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.
It is on the World Health Organization's List of Essential Medicines.
Excerpted from Wikipedia’s “tacalcitol” article, available under the CC BY-SA 4.0 licence.