EMP2

Also known as NPHS10, XMP, epithelial membrane protein 2

Epithelial membrane protein 2 is a protein that in humans is encoded by the EMP2 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to EMP2, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 16.

Vinony links it to 6 Wikipedia language editions.

Gene data

EMP2

Name: epithelial membrane protein 2
Type: protein-coding
Position: 10,528,422–10,580,857 (−)
Aliases: XMP
Ensembl: ENSG00000213853
RefSeq RNA: NM_001424.6
RefSeq protein: NP_001415.1

This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015].