PTBP2

Also known as PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to PTBP2, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 1.

Vinony links it to 5 Wikipedia language editions.

Gene data

PTBP2

Name: polypyrimidine tract binding protein 2
Type: protein-coding
Position: 96,721,284–96,823,738 (+)
Aliases: PTBLP, brPTB, nPTB
Ensembl: ENSG00000117569
RefSeq RNA: NM_001300985.2, NM_001300986.2, NM_001300987.2, NM_001300988.2, NM_001300989.2
RefSeq protein: NP_001287914.1, NP_001287915.1, NP_001287916.1, NP_001287917.1, NP_001287918.1

The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Gene Ontology

Biological process

mRNA processing spinal cord development cerebellum development negative regulation of RNA splicing negative regulation of RNA splicing regulation of RNA splicing

Molecular function

nucleic acid binding RNA binding RNA binding mRNA binding mRNA binding protein binding

Cellular component

nucleus nucleus nucleus spliceosomal complex growth cone neuronal cell body

Pathways

Genes targeted by miRNAs in adipocytes mRNA Processing

via MyGene.info

Gene · Ensembl

polypyrimidine tract binding protein 2

Symbol: PTBP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:96,721,284-96,823,738
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 23162
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/58155
genomic start: 97187221
chromosome: human chromosome 1
genomic end: 97289294
cytogenetic location: 1p21.3

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

Function
References

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.

== Function == The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.

Excerpted from Wikipedia’s “PTBP2” article, available under the CC BY-SA 4.0 licence.