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GeneQ17916811· pop 5· linked from 817 articles

EMX2

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Also known as empty spiracles homeobox 2

Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.

Gene data

EMX2
Name
empty spiracles homeobox 2
Type
protein-coding
Position
117,542,445–117,549,546 (+)
Ensembl
ENSG00000170370
RefSeq RNA
NM_001165924.2, NM_004098.4
RefSeq protein
NP_001159396.1, NP_004089.1

This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009].

Gene Ontology

Pathways

Developmental BiologyFormation of the nephric ductKidney developmentGenes controlling nephrogenesisMammalian disorder of sexual development

via MyGene.info

Wikidata facts

Instance of
gene
Show 6 more facts
HomoloGene ID
3023
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/2018
cytogenetic location
10q26.11
genetic association
schizencephaly
expressed in
germinal epithelium
Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • See also
  • References
  • Further reading
  • External links

Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.

== Function == The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 (MIM 600034) and EMX2 are related to the 'empty spiracles' gene expressed in the developing Drosophila head.[supplied by OMIM].

Excerpted from Wikipedia’s “EMX2” article, available under the CC BY-SA 4.0 licence.

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