Hexokinase 1

Also known as hexokinase IR, hexokinase I, hexokinase-1, hexokinase type I, HK I, hexokinase-A, HK1, brain form hexokinase

mammalian protein found in Homo sapiens

Protein · UniProt

Hexokinase-1

Gene: HK1
Organism: Homo sapiens (Human)
Length: 917 aa
Molecular mass: 102,486 Da
Evidence: 1: Evidence at protein level

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as …

3D-structureAcetylationAllosteric enzymeAlternative splicingATP-bindingCharcot-Marie-Tooth diseaseCytoplasmDirect protein sequencing

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Swiss-Prot (reviewed) · via UniProt