glucose transporter, type 2
Sign in to saveAlso known as Glc_transpt_2, IPR002440, GLUT2, Glucosamine/glucose uniporter, Glut-2, Glucose Transporter Type 2
thumb|right|alt=Glucose transporter 2 (GLUT2) also known as solute carrier family 2, member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes|Glut2basal.png Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood Unlike GLUT4, it does not rely on insulin for facilitated diffusio
Protein · UniProt
Solute carrier family 2, facilitated glucose transporter member 2
- Gene
- SLC2A2
- Organism
- Homo sapiens (Human)
- Length
- 524 aa
- Molecular mass
- 57,490 Da
- Evidence
- 1: Evidence at protein level
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the t…
Swiss-Prot (reviewed) · via UniProt
Research
1,496 papers- Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.Diabetologia · 2018
- Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus.International journal of biological sciences · 2015
- Fructose metabolism and metabolic disease.The Journal of clinical investigation · 2018
- Glucose transporter-2 regulation of VMN GABA neuron metabolic sensor and transmitter gene expression.Scientific reports · 2024
- Glucose transporter 2‑transported glucosamine inhibits glycolysis in cancer cell lines through competition with glucose for hexokinase II.Oncology reports · 2025
via PubMed
Wikidata facts
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- Commons category
- Glucose transporter 2
Sources (3)
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Tissue distribution
- Function
- Clinical significance
- Interactive pathway map
- See also
- References
- External links
thumb|right|alt=Glucose transporter 2 (GLUT2) also known as solute carrier family 2, member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes|Glut2basal.png Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood Unlike GLUT4, it does not rely on insulin for facilitated diffusion.
In humans, this protein is encoded by the SLC2A2 gene.
Excerpted from Wikipedia’s “glucose transporter, type 2” article, available under the CC BY-SA 4.0 licence.