EPOR
Sign in to saveAlso known as EPO-R, erythropoietin receptor
protein-coding gene in the species Homo sapiens
Gene data
EPOR- Name
- erythropoietin receptor
- Type
- protein-coding
- Position
- 11,377,207–11,384,343 (−)
- Aliases
- EPO-R
- Ensembl
- ENSG00000187266
- RefSeq RNA
- NM_000121.4, NR_033663.2
- RefSeq protein
- NP_000112.1
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
erythropoietin receptor
- Symbol
- EPOR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:11,377,207-11,384,343
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI