IL21R

Also known as CD360, NILR, interleukin 21 receptor, IMD56

protein-coding gene in the species Homo sapiens

Gene data

IL21R

Name: interleukin 21 receptor
Type: protein-coding
Position: 27,402,174–27,452,050 (+)
Aliases: CD360, IMD56, NILR
Ensembl: ENSG00000103522
RefSeq RNA: NM_021798.4, NM_181078.3, NM_181079.5, XM_011545857.4, XM_017023257.3
RefSeq protein: NP_068570.1, NP_851564.1, NP_851565.4, XP_011544159.1, XP_016878746.1

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].