EPPIN
Sign in to saveAlso known as CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2, epididymal peptidase inhibitor
Eppin is a protein that in humans is encoded by the SPINLW1 gene.
In the Vinony graph
Within Vinony's link graph, EPPIN is referenced by 2 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 20.
Its subject is documented across 5 Wikipedia language editions.
Gene data
EPPIN- Name
- epididymal peptidase inhibitor
- Type
- protein-coding
- Position
- 45,540,626–45,547,786 (−)
- Aliases
- CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2
- Ensembl
- ENSG00000101448
- RefSeq RNA
- NM_001302861.2, NM_020398.4, NM_181502.1
- RefSeq protein
- NP_001289790.1, NP_065131.1
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
epididymal peptidase inhibitor
- Symbol
- EPPIN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:45,540,626-45,547,786
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 128601
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57119
- genomic end
- 44176391
- genomic start
- 44165625
- chromosome
- human chromosome 20
- cytogenetic location
- 20q13.12
- expressed in
- gonad
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Eppin is a protein that in humans is encoded by the SPINLW1 gene.
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Excerpted from Wikipedia’s “EPPIN” article, available under the CC BY-SA 4.0 licence.