ERVFRD-1
Sign in to saveAlso known as ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, endogenous retrovirus group FRD member 1, endogenous retrovirus group FRD member 1, envelope
Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by ERVFRD-1 gene. It is a member of the HERV-FRD family of endogenous retroviral elements. The human ERVFRD-1 gene is located on chromosome 6. Both Syncytin-2 and Syncytin-1 are encoded by ENV genes and were first identified in a human placenta. Specifically, Syncytin-2 was observed in the cytoplasmic membrane of primary trophoblast cells in the placenta.
In the Vinony graph
Within Vinony's link graph, ERVFRD-1 is referenced by 5 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It sits within the topics Endogenous retroviruses and Genes on human chromosome 6.
Its subject is documented across 6 Wikipedia language editions.
Gene data
ERVFRD-1- Name
- endogenous retrovirus group FRD member 1, envelope
- Type
- protein-coding
- Position
- 11,102,324–11,111,845 (−)
- Aliases
- ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD
- Ensembl
- ENSG00000244476
- RefSeq RNA
- NM_207582.3
- RefSeq protein
- NP_997465.1
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
endogenous retrovirus group FRD member 1, envelope
- Symbol
- ERVFRD-1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:11,102,324-11,111,845
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HERV-FRD PDB 1y4m.png
Show 8 more facts
- HomoloGene ID
- 86779
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/405754
- chromosome
- human chromosome 6
- genomic end
- 11111725
- genomic start
- 11102722
- cytogenetic location
- 6p24.2
- expressed in
- urinary bladder
Sources (4)
via Wikidata · CC0
~6 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Function
- Clinical significance
- Evolution
- References
- Further reading
Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by ERVFRD-1 gene. It is a member of the HERV-FRD family of endogenous retroviral elements. The human ERVFRD-1 gene is located on chromosome 6. Both Syncytin-2 and Syncytin-1 are encoded by ENV genes and were first identified in a human placenta. Specifically, Syncytin-2 was observed in the cytoplasmic membrane of primary trophoblast cells in the placenta.
The receptor for this fusogenic env protein is ASCT-2 and the transporter is MFSD-2. In studies conducted that observed the protein interactions with this receptor, it was additionally found that Syncytin-2 signals were detected at the membrane. This is a place of cell-to-cell contact where this protein can interact with its receptor, in order to be able to induce fusion.
Excerpted from Wikipedia’s “ERVFRD-1” article, available under the CC BY-SA 4.0 licence.