Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by ERVFRD-1 gene. It is a member of the HERV-FRD family of endogenous retroviral elements. The human ERVFRD-1 gene is located on chromosome 6. Both Syncytin-2 and Syncytin-1 are encoded by ENV genes and were first identified in a human placenta. Specifically, Syncytin-2 was observed in the cytoplasmic membrane of primary trophoblast cells in the placenta.
Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by ERVFRD-1 gene. It is a member of the HERV-FRD family of endogenous retroviral elements. The human ERVFRD-1 gene is located on chromosome 6. Both Syncytin-2 and Syncytin-1 are encoded by ENV genes and were first identified in a human placenta. Specifically, Syncytin-2 was observed in the cytoplasmic membrane of primary trophoblast cells in the placenta.
The receptor for this fusogenic env protein is ASCT-2 and the transporter is MFSD-2. In studies conducted that observed the protein interactions with this receptor, it was additionally found that Syncytin-2 signals were detected at the membrane. This is a place of cell-to-cell contact where this protein can interact with its receptor, in order to be able to induce fusion.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).