ERVFRD-1
Sign in to saveAlso known as ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, endogenous retrovirus group FRD member 1, endogenous retrovirus group FRD member 1, envelope
Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by ERVFRD-1 gene. It is a member of the HERV-FRD family of endogenous retroviral elements. The human ERVFRD-1 gene is located on chromosome 6. Both Syncytin-2 and Syncytin-1 are encoded by ENV genes and were first identified in a human placenta. Specifically, Syncytin-2 was observed in the cytoplasmic membrane of primary trophoblast cells in the placenta.
Gene data
ERVFRD-1- Name
- endogenous retrovirus group FRD member 1, envelope
- Type
- protein-coding
- Aliases
- ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012].
via MyGene.info
Gene · Ensembl
endogenous retrovirus group FRD member 1, envelope
- Symbol
- ERVFRD-1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:11,102,324-11,111,845
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein HERV-FRD PDB 1y4m.png
Show 5 more facts
- HomoloGene ID
- 86779
- exact match
- identifiers.org/ncbigene/405754
- genomic end
- 11111725
- genomic start
- 11102722
- cytogenetic location
- 6p24.2
Sources (4)
via Wikidata · CC0
~6 min read
Article
6 sectionsContents
- Structure
- Function
- Clinical significance
- Evolution
- References
- Further reading
Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by ERVFRD-1 gene. It is a member of the HERV-FRD family of endogenous retroviral elements. The human ERVFRD-1 gene is located on chromosome 6. Both Syncytin-2 and Syncytin-1 are encoded by ENV genes and were first identified in a human placenta. Specifically, Syncytin-2 was observed in the cytoplasmic membrane of primary trophoblast cells in the placenta.
The receptor for this fusogenic env protein is ASCT-2 and the transporter is MFSD-2. In studies conducted that observed the protein interactions with this receptor, it was additionally found that Syncytin-2 signals were detected at the membrane. This is a place of cell-to-cell contact where this protein can interact with its receptor, in order to be able to induce fusion.