ERLIN2
Sign in to saveAlso known as C8orf2, Erlin-2, NET32, SPFH2, SPG18, ER lipid raft associated 2
Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.
In the Vinony graph
Within Vinony's link graph, ERLIN2 is referenced by 3 other articles, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 8.
Its subject is documented across 5 Wikipedia language editions.
Gene data
ERLIN2- Name
- ER lipid raft associated 2
- Type
- protein-coding
- Position
- 37,736,587–37,758,422 (+)
- Aliases
- C8orf2, Erlin-2, NET32, SPFH2, SPG18, SPG18A, SPG18B
- Ensembl
- ENSG00000147475
- RefSeq RNA
- NM_001003790.4, NM_001003791.3, NM_001362878.2, NM_001362880.2, NM_007175.8
- RefSeq protein
- NP_001003790.1, NP_001003791.1, NP_001349807.1, NP_001349809.1, NP_009106.1
This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
ER lipid raft associated 2
- Symbol
- ERLIN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:37,736,587-37,758,422
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 5193
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11160
- genomic end
- 37758422
- genomic start
- 37736601
- chromosome
- human chromosome 8
- cytogenetic location
- 8p11.23
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.
== References ==
Excerpted from Wikipedia’s “ERLIN2” article, available under the CC BY-SA 4.0 licence.