Structure via PubChem · Public domain (PubChem)
esculetin
Sign in to saveAlso known as 6,7-dihydroxycoumarin, aesculetin, cichorigenin, cichoriin aglucon, esculin aglycon, cichoriin aglycon, 6,7-dihydroxy-2H-1-benzopyran-2-one, esculin aglucon
Aesculetin (also known as esculetin, 6,7-dihydroxycoumarin and cichorigenin) is a derivative of coumarin. It is a natural lactone that derives from the intramolecular cyclization of a cinnamic acid derivative.
Chemical data
- Formula
- C9H6O4
- Molecular weight
- 178.14 g/mol
- IUPAC name
- 6,7-dihydroxychromen-2-one
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
910 papers- Esculetin: A review of its pharmacology and pharmacokinetics.Phytotherapy research : PTR · 2022
- Esculetin unveiled: Decoding its anti-tumor potential through molecular mechanisms-A comprehensive review.Cancer reports (Hoboken, N.J.) · 2024
- Esculetin rebalances M1/M2 macrophage polarization to treat sepsis-induced acute lung injury through regulating metabolic reprogramming.Journal of cellular and molecular medicine · 2024
- Pharmacological and Therapeutic Applications of Esculetin.International journal of molecular sciences · 2022
- Esculetin inhibits liver cancer by targeting glucose-6-phosphate isomerase mediated glycolysis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
via PubMed
Wikidata facts
- Mass
- 178.026609
Show 4 more facts
- chemical formula
- C₉H₆O₄
- canonical SMILES
- C1=CC(=O)OC2=CC(=C(C=C21)O)O
- subject has role
- antioxidant
- different from
- esculin
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Aesculetin (also known as esculetin, 6,7-dihydroxycoumarin and cichorigenin) is a derivative of coumarin. It is a natural lactone that derives from the intramolecular cyclization of a cinnamic acid derivative.
It is present in chicory and in many toxic and medicinal plants, in form of glycosides and caffeic acid conjugates.
Excerpted from Wikipedia’s “esculetin” article, available under the CC BY-SA 4.0 licence.