Structure via PubChem · Public domain (PubChem)
esculetin
Sign in to saveAlso known as 6,7-dihydroxycoumarin, aesculetin, cichorigenin, cichoriin aglucon, esculin aglycon, cichoriin aglycon, 6,7-dihydroxy-2H-1-benzopyran-2-one, esculin aglucon
Aesculetin (also known as esculetin, 6,7-dihydroxycoumarin and cichorigenin) is a derivative of coumarin. It is a natural lactone that derives from the intramolecular cyclization of a cinnamic acid derivative.
Chemical data
- Formula
- C9H6O4
- Molecular weight
- 178.14 g/mol
- IUPAC name
- 6,7-dihydroxychromen-2-one
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
910 papers- Esculetin: A review of its pharmacology and pharmacokinetics.Phytotherapy research : PTR · 2022
- Esculetin unveiled: Decoding its anti-tumor potential through molecular mechanisms-A comprehensive review.Cancer reports (Hoboken, N.J.) · 2024
- Esculetin rebalances M1/M2 macrophage polarization to treat sepsis-induced acute lung injury through regulating metabolic reprogramming.Journal of cellular and molecular medicine · 2024
- Pharmacological and Therapeutic Applications of Esculetin.International journal of molecular sciences · 2022
- Esculetin inhibits liver cancer by targeting glucose-6-phosphate isomerase mediated glycolysis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
via PubMed
Wikidata facts
- Mass
- 178.026609
Show 2 more facts
- chemical formula
- C₉H₆O₄
- canonical SMILES
- C1=CC(=O)OC2=CC(=C(C=C21)O)O
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- See also
- References
Aesculetin (also known as esculetin, 6,7-dihydroxycoumarin and cichorigenin) is a derivative of coumarin. It is a natural lactone that derives from the intramolecular cyclization of a cinnamic acid derivative.
It is present in chicory and in many toxic and medicinal plants, in form of glycosides and caffeic acid conjugates.