Structure via PubChem · Public domain (PubChem)
hymecromone
Sign in to saveAlso known as beta-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran, 4-Methyl-7-hydroxycoumarin, 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one, 7-Hydroxy-4-methyl-2-oxo-3-chromene, Imecromone, 4-MU
Hymecromone (4-methylumbelliferone) is a drug used in bile therapy. It is used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity.
Chemical data
- Formula
- C10H8O3
- Molecular weight
- 176.17 g/mol
- IUPAC name
- 7-hydroxy-4-methylchromen-2-one
- SMILES
- CC1=CC(=O)OC2=C1C=CC(=C2)O
- InChIKey
- HSHNITRMYYLLCV-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 46.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- respiratory system disease, sclerosing cholangitis, pulmonary hypertension
via ChEMBL · EBI
Research
1,257 papers- Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression.Signal transduction and targeted therapy · 2022
- Oral hymecromone decreases hyaluronan in human study participants.The Journal of clinical investigation · 2022
- Inverting glucuronidation of hymecromone in situ by catalytic nanocompartments.Journal of materials chemistry. B · 2022
- Pharmacokinetics and bioavailabilities of hymecromone in human volunteers.Biopharmaceutics & drug disposition · 1993
- [Bile acid-independent effect of hymecromone on bile secretion and common bile duct motility].Deutsche medizinische Wochenschrift (1946) · 2005
via PubMed
Wikidata facts
- Mass
- 176.047
Show 5 more facts
- melting point
- 189
- chemical formula
- C₁₀H₈O₃
- canonical SMILES
- CC1=CC(=O)OC2=C1C=CC(=C2)O
- World Health Organisation international non-proprietary name
- hymecromone
- Commons category
- Hymecromone
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Hymecromone (4-methylumbelliferone) is a drug used in bile therapy. It is used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity.
Hymecromone is a crystalline solid with a melting point of 194–195 °C. It is soluble in methanol and glacial acetic acid.
Excerpted from Wikipedia’s “hymecromone” article, available under the CC BY-SA 4.0 licence.