FGFBP1

Also known as FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Gene data

FGFBP1

Name: fibroblast growth factor binding protein 1
Type: protein-coding
Position: 15,934,507–15,939,171 (−)
Aliases: FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17
Ensembl: ENSG00000137440
RefSeq RNA: NM_005130.5
RefSeq protein: NP_005121.1

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011].

Gene Ontology

Biological process

signal transduction cell-cell signaling cell-cell signaling negative regulation of cell population proliferation positive regulation of cell migration involved in sprouting angiogenesis positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Molecular function

protein binding heparin binding fibroblast growth factor binding growth factor binding

Cellular component

extracellular region extracellular region plasma membrane cell surface

Pathways

Signal Transduction Signaling by FGFR FGFR2 ligand binding and activation FGFR2b ligand binding and activation Signaling by FGFR2 Signaling by Receptor Tyrosine Kinases Glucocorticoid Receptor Pathway Nuclear Receptors Meta-Pathway

via MyGene.info

Gene · Ensembl

fibroblast growth factor binding protein 1

Symbol: FGFBP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:15,934,507-15,948,427
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 3766
exact match: identifiers.org/ncbigene/9982
genomic end: 15940363
genomic start: 15935577
cytogenetic location: 4p15.32

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Further reading

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).[supplied by OMIM]