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GeneQ14912032· pop 6· linked from 98 articles

GDF1

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Also known as DORV, DTGA3, RAI, growth differentiation factor 1, CHTD6, UOG1, LASS1, CERS1

Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.

Gene data

GDF1
Name
growth differentiation factor 1
Type
protein-coding
Position
18,868,545–18,896,158 (−)
Aliases
CHTD6, DORV, DTGA3, RAI
Ensembl
ENSG00000130283
RefSeq RNA
NM_001387438.1, NM_001492.6
RefSeq protein
NP_001374367.1, NP_001483.3

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016].

Gene Ontology

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)Signaling by NODALDevelopmental Biology

via MyGene.info

Gene · Ensembl

growth differentiation factor 1

Symbol
GDF1
Biotype
Protein coding
Organism
Homo sapiens
Location
19:18,868,545-18,896,158
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.

GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development. It is found in the brain, spinal cord and peripheral nerves of embryos.

Excerpted from Wikipedia’s “GDF1” article, available under the CC BY-SA 4.0 licence.

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