FHIT
Sign in to saveAlso known as AP3Aase, FRA3B, fragile histidine triad, tríada histidina fràgil, fragile histidine triad diadenosine triphosphatase
'''Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein' (FHIT) is an enzyme that in humans is encoded by the FHIT'' gene.
Gene data
FHIT- Name
- fragile histidine triad diadenosine triphosphatase
- Type
- protein-coding
- Aliases
- AP3Aase, FRA3B
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017].
via MyGene.info
Wikidata facts
- Image
- Protein FHIT PDB 1fhi.png
Show 5 more facts
- HomoloGene ID
- 21661
- exact match
- identifiers.org/ncbigene/2272
- genomic start
- 59747277
- genomic end
- 61237133
- cytogenetic location
- 3p14.2
Sources (8)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- External links
'''Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein' (FHIT) is an enzyme that in humans is encoded by the FHIT'' gene.
== Function ==