Structure via PubChem · Public domain (PubChem)
flutoprazepam
Sign in to saveFlutoprazepam (Restas) is a drug which is a benzodiazepine. It was patented in Japan by Sumitomo in 1972 and its medical use remains mostly confined to that country. Its muscle relaxant properties are approximately equivalent to those of diazepam - however, it has more powerful sedative, hypnotic, anxiolytic and anticonvulsant effects and is around four times more potent by weight compared to diazepam. It is longer acting than diazepam due to its long-acting active metabolites, which contribute significantly to its effects. Its principal active metabolite is n-desalkylflurazepam, also known as
In the Vinony graph
Vinony's link graph records 638 inbound references to flutoprazepam, and connects out to benzodiazepine drug, alphenal and norflurazepam.
Vinony files it under 2-Fluorophenyl compounds, Benzodiazepines and Chemical pages without DrugBank identifier.
Vinony links it to 9 Wikipedia language editions.
Chemical data
- Formula
- C19H16ClFN2O
- Molecular weight
- 342.8 g/mol
- IUPAC name
- 7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
- SMILES
- C1CC1CN2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4F
- InChIKey
- OFVXPDXXVSGEPX-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 342.094
Show 4 more facts
- chemical formula
- C₁₉H₁₆ClFN₂O
- canonical SMILES
- C1CC1CN2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4F
- medical condition treated
- anxiety disorder
- Commons category
- Flutoprazepam
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Flutoprazepam (Restas) is a drug which is a benzodiazepine. It was patented in Japan by Sumitomo in 1972 and its medical use remains mostly confined to that country. Its muscle relaxant properties are approximately equivalent to those of diazepam - however, it has more powerful sedative, hypnotic, anxiolytic and anticonvulsant effects and is around four times more potent by weight compared to diazepam. It is longer acting than diazepam due to its long-acting active metabolites, which contribute significantly to its effects. Its principal active metabolite is n-desalkylflurazepam, also known as norflurazepam, which is also a principal metabolite of flurazepam (trade name Dalmadorm/Dalmane).
Flutoprazepam is typically used for the treatment of severe insomnia and may also be used for treating stomach ulcers.
Excerpted from Wikipedia’s “flutoprazepam” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0