Forkhead box O3
Sign in to saveAlso known as forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1, FOXO3, forkhead in rhabdomyosarcoma-like 1, forkhead box protein O3, forkhead homolog (rhabdomyosarcoma) like 1, forkhead box O3A, AF6q21 protein
Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.
Protein · UniProt
Forkhead box protein O3
- Gene
- FOXO3
- Organism
- Homo sapiens (Human)
- Length
- 673 aa
- Molecular mass
- 71,277 Da
- Evidence
- 1: Evidence at protein level
Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival facto…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- UNKNOWNPTEN-AKT-FOXO3 Gene Expression Relation With Low-ovarian Reserve in EndometriomasUludag University · NCT04058912
Wikidata facts
- Instance of
- protein
Show 3 more facts
- biological process
- response to starvation
- cell component
- cytoplasm
- found in taxon
- Homo sapiens
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- Function
- Apoptosis
- Stem cells
- Clinical significance
- Association with longevity
- Association with intelligence
- See also
- References
- Further reading
- External links
Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.
== Function ==
Excerpted from Wikipedia’s “Forkhead box O3” article, available under the CC BY-SA 4.0 licence.