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GeneQ5426911· pop 5· linked from 815 articles

FOSL2

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Also known as Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 transcription factor subunit

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.

Gene data

FOSL2
Name
FOS like 2, AP-1 transcription factor subunit
Type
protein-coding
Position
28,392,448–28,417,317 (+)
Aliases
ACED, FRA2
Ensembl
ENSG00000075426
RefSeq RNA
NM_005253.4, XM_005264231.5, XM_006711976.4, XM_006711977.4, XM_054341221.1
RefSeq protein
NP_005244.1, XP_005264288.1, XP_006712039.1, XP_006712040.1, XP_054197196.1

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014].

Gene Ontology

Pathways

Osteoclast differentiation - Homo sapiens (human)Corticotropin-releasing hormone signaling pathway

via MyGene.info

Gene · Ensembl

FOS like 2, AP-1 transcription factor subunit

Symbol
FOSL2
Biotype
Protein coding
Organism
Homo sapiens
Location
2:28,392,448-28,417,317
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
3845
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/2355
genomic end
28417317
genomic start
28615315
chromosome
human chromosome 2
cytogenetic location
2p23.2
expressed in
pericardium
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • See also
  • References
  • Further reading
  • External links

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.

== Function == The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

Excerpted from Wikipedia’s “FOSL2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0