FOXK1

Also known as FOXK1L, forkhead box K1

Forkhead box protein K1 is a transcription factor of the forkhead box family that in humans is encoded by the FOXK1 gene.

Gene data

FOXK1

Name: forkhead box K1
Type: protein-coding
Position: 4,682,295–4,771,442 (+)
Aliases: FOXK1L
Ensembl: ENSG00000164916
RefSeq RNA: NM_001037165.2
RefSeq protein: NP_001032242.1

Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II intracellular glucose homeostasis regulation of DNA-templated transcription regulation of transcription by RNA polymerase II negative regulation of autophagy regulation of glucose metabolic process response to starvation negative regulation of DNA-templated transcription

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm

Pathways

Metabolism of proteins Deubiquitination UCH proteinases Post-translational protein modification

via MyGene.info

Wikidata facts

Image: Protein FOXK1 PDB 2a3s.png

Show 5 more facts

HomoloGene ID: 82414
exact match: identifiers.org/ncbigene/221937
genomic end: 4771442
genomic start: 4682295
cytogenetic location: 7p22.1

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Forkhead box protein K1 is a transcription factor of the forkhead box family that in humans is encoded by the FOXK1 gene.

During starvation, in type 2 diabetes, in rapidly dividing cells during embryogenesis, in tumors (Warburg effect) and during T cell proliferation, aerobic glycolysis is induced to produce the building block to sustain growth. FOXK1 is one of the transcription factors managing the passage from the normal cellular respiration (complete glucose oxidation) to generating ATP and intermediaries for many other biochemical pathways.