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GeneQ17928773· pop 10· linked from 824 articles

FOXM1

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Also known as FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2

Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription factors. Its potential as a target for future cancer treatments led to it being designated the 2010 Molecule of the Year.

Gene data

FOXM1
Name
forkhead box M1
Type
protein-coding
Position
2,857,676–2,877,197 (−)
Aliases
FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2
Ensembl
ENSG00000111206
RefSeq RNA
NM_001243088.2, NM_001243089.2, NM_001413925.1, NM_001413926.1, NM_001413927.1
RefSeq protein
NP_001230017.1, NP_001230018.1, NP_001400854.1, NP_001400855.1, NP_001400856.1

The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

Gene Ontology

Pathways

Cellular senescence - Homo sapiens (human)Polo-like kinase mediated eventsCell CycleDiseaseMitotic G2-G2/M phasesDiseases of signal transduction by growth factor receptors and second messengersCyclin A/B1/B2 associated events during G2/M transitionG2/M TransitionCell Cycle, MitoticSignaling by ALK in cancer

via MyGene.info

Gene · Ensembl

forkhead box M1

Symbol
FOXM1
Biotype
Protein coding
Organism
Homo sapiens
Location
12:2,857,676-2,877,197
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

10 sections
Contents
  • Function
  • Cancer link
  • Isoforms
  • Mechanism of oncogenesis
  • Role in stem cell fate
  • Role in epigenome regulations
  • Interactions
  • See also
  • References
  • External links

Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription factors. Its potential as a target for future cancer treatments led to it being designated the 2010 Molecule of the Year.

== Function ==

Excerpted from Wikipedia’s “FOXM1” article, available under the CC BY-SA 4.0 licence.

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