FOXP1
Sign in to saveAlso known as 12CC4, HSPC215, MFH, QRF1, hFKH1B, forkhead box P1
Forkhead box protein P1 is a protein that in humans is encoded by the FOXP1 gene. FOXP1 is necessary for the proper development of the brain, heart, and lung in mammals. It is a member of the large FOX family of transcription factors.
Gene data
FOXP1- Name
- forkhead box P1
- Type
- protein-coding
- Position
- 70,954,693–71,584,009 (−)
- Aliases
- 12CC4, HSPC215, MFH, QRF1, hFKH1B
- Ensembl
- ENSG00000114861
- RefSeq RNA
- NM_001012505.2, NM_001244808.3, NM_001244810.2, NM_001244812.3, NM_001244813.3
- RefSeq protein
- NP_001012523.1, NP_001231737.1, NP_001231739.1, NP_001231741.1, NP_001231742.1
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
forkhead box P1
- Symbol
- FOXP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:70,954,693-71,584,009
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- FOXP1.png
Show 8 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 136512
- exact match
- identifiers.org/ncbigene/27086
- cytogenetic location
- 3p13
- chromosome
- human chromosome 3
- genomic start
- 70954693
- genomic end
- 71583978
- expressed in
- lactiferous duct
Sources (6)
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Function
- See also
- References
- Further reading
- External links
Forkhead box protein P1 is a protein that in humans is encoded by the FOXP1 gene. FOXP1 is necessary for the proper development of the brain, heart, and lung in mammals. It is a member of the large FOX family of transcription factors.
== Function == This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “FOXP1” article, available under the CC BY-SA 4.0 licence.