GBX2
Sign in to saveAlso known as gastrulation brain homeobox 2
Homeobox protein GBX-2 is a protein that in humans is encoded by the GBX2 gene.
Gene data
GBX2- Name
- gastrulation brain homeobox 2
- Type
- protein-coding
- Position
- 236,165,236–236,168,395 (−)
- Ensembl
- ENSG00000168505
- RefSeq RNA
- NM_001301687.2, NM_001485.4, XM_047443907.1, XM_054341355.1
- RefSeq protein
- NP_001288616.1, NP_001476.2, XP_047299863.1, XP_054197330.1
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of nervous system development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including branching involved in blood vessel morphogenesis; nervous system development; and neural crest cell migration. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
gastrulation brain homeobox 2
- Symbol
- GBX2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:236,165,236-236,168,395
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~5 min read
Encyclopedic overview
6 sectionsContents
- Summary
- Function
- Neural Crest Cell Development
- Animal studies
- References
- Further reading
Homeobox protein GBX-2 is a protein that in humans is encoded by the GBX2 gene.
== Summary == Gastrulation Brain Homeobox 2, or commonly known as GBX2, is a type of transcription factor that aids in the arranging of the midbrain and hindbrain during gastrulation. The hindbrain is broken up into seven or eight rhombomeres during gastrulation and GBX2 is responsible for rhombomeres one through three. GBX2 also takes part in the signaling and expression of other genes. It has been said that there is a threshold requirement for the amount of GBX2, so what occurs depends on the amount expressed. For example, specific amounts of GBX2 is needed for regulating the anterior and posterior patterning in the hindbrain. If the specific threshold is not met, then the patterning does not occur. This is the case with the other genes it helps to express like FGF8. With every gene comes some diseases associated with it. Colon Small Cell Carcinoma and Optiz-Gbbb Syndrome, which causes abnormalities throughout the midline of the body, are the diseases most closely associated with the GBX2 gene.
Excerpted from Wikipedia’s “GBX2” article, available under the CC BY-SA 4.0 licence.