deflazacort

Also known as MDL 458, Calcort

Deflazacort, sold under the brand name Calcort among others, is a glucocorticoid belonging to acetonides or O-isopropylidene derivative. It is used as an anti-inflammatory and was patented in 1969 and approved for medical use in 1985. The US Food and Drug Administration considers it to be a first-in-class medication for Duchenne Muscular Dystrophy.

Key facts

Drug.verifiedrevid: 447631837
Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.image: Deflazacort structure.svg
Drug.image_class: skin-invert-image
Drug.tradename: Emflaza, Calcort, others
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: H02
Drug.ATC_suffix: AB13
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.protein_bound: 40%
Drug.metabolism: By plasma esterases, to active metabolite
Drug.elimination_half life: 1.1–1.9 hours (metabolite)
Drug.excretion: Kidney (70%) and fecal (30%)
Drug.CAS_number: 14484-47-0
Drug.PubChem: 189821
Drug.DrugBank: DB11921

via Wikipedia infobox

Research

710 papers

Comparing Deflazacort and Prednisone in Duchenne Muscular Dystrophy.Journal of neuromuscular diseases · 2022
[Deflazacort-induced Steven-Johnson syndrome: a case report and literature review].Zhonghua er ke za zhi = Chinese journal of pediatrics · 2024
Deflazacort.Journal of postgraduate medicine · 2009
Deflazacort--an alternative to prednisolone?Drug and therapeutics bulletin · 1999
Deflazacort: therapeutic index, relative potency and equivalent doses versus other corticosteroids.BMC pharmacology & toxicology · 2017

via PubMed

Wikidata facts

Mass: 441.21513771199994

Show 6 more facts

World Health Organisation international non-proprietary name: deflazacort
canonical SMILES: CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C
chemical formula: C₂₅H₃₁NO₆
isomeric SMILES: CC1=N[C@@]2([C@H](O1)C[C@@H]3[C@@]2(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)C(=O)COC(=O)C
Commons category: Deflazacort
defined daily dose: 15

Sources (4)

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