Structure via PubChem · Public domain (PubChem)
glecaprevir
Sign in to saveGlecaprevir (INN,) is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that was identified jointly by AbbVie and Enanta Pharmaceuticals. It is being developed as a treatment of chronic hepatitis C infection in co-formulation with an HCV NS5A inhibitor pibrentasvir. Together they demonstrated potent antiviral activity against major HCV genotypes and high barriers to resistance in vitro.
Chemical data
- Formula
- C38H46F4N6O9S
- Molecular weight
- 838.9 g/mol
- IUPAC name
- (1R,14E,18R,22R,26S,29S)-26-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonylcarbamoyl]cyclopropyl]-13,13-difluoro-24,27-dioxo-2,17,23-trioxa-4,11,25,28-tetrazapentacyclo[26.2.1.03,12.05,10.018,22]hentriaconta-3,5,7,9,11,14-hexaene-29-carboxamide
- SMILES
- CC1(CC1)S(=O)(=O)NC(=O)[C@]2(C[C@H]2C(F)F)NC(=O)[C@@H]3C[C@@H]4CN3C(=O)[C@@H](NC(=O)O[C@@H]5CCC[C@H]5OC/C=C/C(C6=NC7=CC=CC=C7N=C6O4)(F)F)C(C)(C)C
- InChIKey
- MLSQGNCUYAMAHD-ITNVBOSISA-N
- XLogP
- 4.6
- Polar surface area
- 204 Ų
- H-bond donors
- 3
- H-bond acceptors
- 15
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- oral
- Indications
- liver disease, hepatitis C virus infection, chronic hepatitis C virus infection, kidney disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 838.9
- Has use
- medication
Show 1 more fact
- chemical formula
- C₃₈H₄₆F₄N₆O₉S
Sources (1)
via Wikidata · CC0
~3 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
{{Drugbox | IUPAC_name = (3aR,7S,10S,12R,21E,24aR)-7-tert-Butyl-N-{(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropane-1-sulfonyl)carbamoyl]cyclopropyl}-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17,3,6]trioxadiazacyclonon adecino[11,12-b]quinoxaline-10-carboxamide | image = Glecaprevir.svg | image_class = skin-invert-image | width =
| tradename = Mavyret (combination with pibrentasvir) | Drugs.com = | licence_US = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth
Excerpted from Wikipedia’s “glecaprevir” article, available under the CC BY-SA 4.0 licence.