amantadine
Sign in to saveAmantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended because of widespread drug resistance. It is also used for a variety of other conditions. The drug is taken by mouth.
Research
8,746 papers- [Amantadine].Nihon rinsho. Japanese journal of clinical medicine · 2003
- Extended-Release Amantadine for Levodopa-Induced Dyskinesia.Expert review of neurotherapeutics · 2019
- Amantadine Revisited: A Contender for Initial Treatment in Parkinson's Disease?CNS drugs · 2021
- Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review.Neurocritical care · 2020
- Adamantine Amantadine.Journal of general internal medicine · 2025
via PubMed
Article
36 sectionsContents
- Medical uses
- Parkinson's disease
- Influenza A
- Extrapyramidal symptoms
- Off-label uses
- Fatigue in multiple sclerosis
- Disorders of consciousness
- Brain injury recovery
- Contraindications
- Side effects
- Neurological
- Cardiovascular
- Gastrointestinal
- Skin
- Kidney
- Pregnancy and lactation
- Interactions
- Pharmacology
- Mechanism of action
- Central nervous system disorders
- Influenza
- Pharmacokinetics
- Chemistry
- History
- Influenza A
- Parkinson's disease
- Society and culture
- Names
- Recreational use
- Veterinary misuse
- Research
- Depression
- Attention deficit hyperactivity disorder
- COVID-19
- References
- External links
Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended because of widespread drug resistance. It is also used for a variety of other conditions. The drug is taken by mouth.
Amantadine has a mild side-effect profile. Common neurological side effects include drowsiness, lightheadedness, dizziness, and confusion. Because of its effects on the central nervous system (CNS), it should be combined cautiously with additional CNS stimulants or anticholinergic drugs. Given that it is cleared by the kidneys, amantadine is contraindicated in persons with end-stage kidney disease. Due to its anticholinergic effects, it should be taken with caution by those with enlarged prostates or glaucoma.
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Categories
AdamantanesAminesAntidyskinetic agentsAnti-influenza agentsAntiparkinsonian agentsAnti–RNA virus drugsAttention deficit hyperactivity disorder managementChemical articles with multiple CAS registry numbersChemical articles with multiple ChEBIsChemical articles with multiple PubChem CIDsChemicals using indexlabelsDesigner drugs