GLP2R

Name

glucagon like peptide 2 receptor

Type

protein-coding

Position

9,822,206–9,894,163 (+)

Ensembl

ENSG00000065325

RefSeq RNA

NM_004246.3, XM_011524077.4, XM_017025339.2, XM_017025340.2, XM_017025341.2

RefSeq protein

NP_004237.1, XP_011522379.1, XP_016880828.1, XP_016880829.1, XP_016880830.1

This gene encodes a G protein-coupled receptor closely related to the glucagon receptor that binds glucagon-like peptide 2 (GLP-2). Activation of this gene stimulates intestinal growth by increasing villus height, enhancing crypt cell proliferation, and reducing enterocyte apoptosis, thereby promoting nutrient absorption and maintaining gut barrier integrity. Glucagon like protein 2 receptor signaling also regulates intestinal blood flow, supports mucosal healing after injury, and modulates gut hormone secretion. In addition, it has been implicated in metabolic homeostasis and may influence energy balance and glucose metabolism. Dysregulation of this receptor or its signaling pathways is associated with intestinal disorders, including short bowel syndrome and inflammatory bowel disease. This receptor is a potential therapeutic target for enhancing intestinal regeneration and treating gastrointestinal diseases. [provided by RefSeq, Mar 2026].

via MyGene.info

Gene · Ensembl

glucagon like peptide 2 receptor

Symbol

GLP2R

Biotype

Protein coding

Organism

Homo sapiens

Location

17:9,822,206-9,894,163

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

GLP2R.png

via Wikidata · CC0