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GeneQ18040102· pop 5· linked from 97 articles

GLRX5

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Also known as C14orf87, FLB4739, GRX5, PR01238, PRO1238, PRSA, SIDBA3, SPAHGC

Glutaredoxin 5, also known as GLRX5, is a protein which in humans is encoded by the GLRX5 gene located on chromosome 14. This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron- sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.

Gene data

GLRX5
Name
glutaredoxin 5
Type
protein-coding
Position
95,533,503–95,544,724 (+)
Aliases
C14orf87, FLB4739, GRX5, PR01238, PRO1238, PRSA, SIDBA3, SPAHGC
Ensembl
ENSG00000182512
RefSeq RNA
NM_016417.3
RefSeq protein
NP_057501.2

This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010].

Gene Ontology

Pathways

Mitochondrial iron-sulfur cluster biogenesisMetabolism

via MyGene.info

Gene · Ensembl

glutaredoxin 5

Symbol
GLRX5
Biotype
Protein coding
Organism
Homo sapiens
Location
14:95,533,503-95,544,724
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
31984
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/51218
genomic end
96011061
genomic start
95999840
chromosome
human chromosome 14
cytogenetic location
14q32.13
expressed in
right ventricle
Sources (6)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections
Contents
  • Structure
  • Function
  • Clinical significance
  • See also
  • References
  • Further reading

Glutaredoxin 5, also known as GLRX5, is a protein which in humans is encoded by the GLRX5 gene located on chromosome 14. This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron- sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.

== Structure ==

Excerpted from Wikipedia’s “GLRX5” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0