UCP2

Name

uncoupling protein 2

Type

protein-coding

Position

73,973,431–73,983,542 (−)

Aliases

BMIQ4, SLC25A8, UCPH

Ensembl

ENSG00000175567

RefSeq RNA

NM_001381943.1, NM_001381944.1, NM_001381945.1, NM_001381947.1, NM_001381948.1

RefSeq protein

NP_001368872.1, NP_001368873.1, NP_001368874.1, NP_001368876.1, NP_001368877.1

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

uncoupling protein 2

Symbol

UCP2

Biotype

Protein coding

Organism

Homo sapiens

Location

11:73,973,431-73,983,542

Strand

Reverse (−)

Assembly

GRCh38