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GeneQ18026168· pop 5· linked from 61 articles

GLUD2

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Also known as GDH2, GLUDP1, glutamate dehydrogenase 2

Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene. This dehydrogenase is one of the family of glutamate dehydrogenases that are ubiquitous in life.

In the Vinony graph

Within Vinony's link graph, GLUD2 is referenced by 61 other articles, and connects out to PubMed, X chromosome and Ensembl genome database project.

Vinony files it under EC 1.4.1 and Genes on human chromosome X.

Its subject is documented across 5 Wikipedia language editions.

Gene data

GLUD2

Name: glutamate dehydrogenase 2
Type: protein-coding
Chromosome: X
Position: 121,047,610–121,050,094 (+)
Aliases: GDH2, GLUDP1
Ensembl: ENSG00000288118
RefSeq RNA: NM_012084.4
RefSeq protein: NP_036216.2

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010].

Gene Ontology

Biological process

amino acid metabolic process glutamate metabolic process L-glutamate catabolic process L-glutamate catabolic process L-glutamate catabolic process L-glutamate biosynthetic process

Molecular function

L-glutamate dehydrogenase (NAD+) activity L-glutamate dehydrogenase (NAD+) activity L-glutamate dehydrogenase (NAD+) activity L-glutamate dehydrogenase [NAD(P)+] activity L-glutamate dehydrogenase [NAD(P)+] activity L-glutamate dehydrogenase (NADP+) activity protein binding GTP binding

Cellular component

mitochondrion mitochondrion mitochondrion mitochondrial matrix cytosol

Pathways

Arginine biosynthesis - Homo sapiens (human)Alanine, aspartate and glutamate metabolism - Homo sapiens (human)D-Glutamine and D-glutamate metabolism - Homo sapiens (human)Nitrogen metabolism - Homo sapiens (human)Necroptosis - Homo sapiens (human)Proximal tubule bicarbonate reclamation - Homo sapiens (human)Metabolism Mitochondrial biogenesis Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis

via MyGene.info

Gene · Ensembl

glutamate dehydrogenase 2

Symbol: GLUD2
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr X:121,047,610-121,050,094
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: PDB 1hwx EBI.jpg

Show 7 more facts

found in taxon: Homo sapiens
HomoloGene ID: 115647
exact match: identifiers.org/ncbigene/2747
chromosome: human X chromosome
genomic start: 121047610
genomic end: 121050094
cytogenetic location: Xq24

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene. This dehydrogenase is one of the family of glutamate dehydrogenases that are ubiquitous in life.

== Function ==

Excerpted from Wikipedia’s “GLUD2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

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Categories

EC 1.4.1 Genes on human chromosome X