MERTK
Sign in to saveAlso known as MER, RP38, c-mer, Tyro12, c-Eyk, MER proto-oncogene, tyrosine kinase
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.
Gene data
MERTK- Name
- MER proto-oncogene, tyrosine kinase
- Type
- protein-coding
- Position
- 111,898,456–112,040,637 (+)
- Aliases
- MER, RP38, Tyro12, c-Eyk, c-mer
- Ensembl
- ENSG00000153208
- RefSeq RNA
- NM_006343.3
- RefSeq protein
- NP_006334.2
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
MER proto-oncogene, tyrosine kinase
- Symbol
- MERTK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:111,898,456-112,040,637
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MERTK PDB 2dbj.png
Show 8 more facts
- HomoloGene ID
- 4626
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10461
- genomic end
- 112787138
- genomic start
- 111898607
- chromosome
- human chromosome 2
- cytogenetic location
- 2q13
- expressed in
- spleen
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.
== Function ==
Excerpted from Wikipedia’s “MERTK” article, available under the CC BY-SA 4.0 licence.