hexokinase
Sign in to saveA hexokinase is an enzyme that irreversibly phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate.
Key facts
- Protein.OMIM
- 142570
- Protein.Name
- hexokinase 3 (white cell)
- Protein.caption
- Hexokinase 1, homodimer, Human
- Protein.image
- 1hkc.jpg
- Protein.width
- 270
- Protein.HGNCid
- 4925
- Protein.Symbol
- HK3
- Protein.EntrezGene
- 3101
- Protein.RefSeq
- NM_002115
- Protein.UniProt
- P52789
- Protein.Chromosome
- 2
- Protein.Arm
- p
- Protein.Band
- 35.2
- Protein family.Symbol
- Hexokinase_2
- Protein family.Name
- Hexokinase_2
- Protein family.image
- PDB 1bg3 EBI.jpg
- Protein family.caption
- rat brain hexokinase type i complex with glucose and inhibitor glucose-6-phosphate
- Protein family.Pfam
- PF03727
via Wikipedia infobox
Article
12 sectionsContents
- Variation
- Reaction
- Consequences of hexose phosphorylation
- Size of different isoforms
- Types of mammalian hexokinase
- Hexokinases I, II, and III
- Hexokinase IV ("glucokinase")
- In glycolysis
- Association with mitochondria
- Deficiency
- See also
- References
A hexokinase is an enzyme that irreversibly phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate.
Hexokinases should not be confused with glucokinase, which is a specific hexokinase found in the liver. All hexokinases are capable of phosphorylating several hexoses but hexokinase IV(D) is often misleadingly called glucokinase, though it is no more specific for glucose than the other mammalian isoenzymes.