HMG-box
Sign in to saveIn molecular biology, the HMG-box (high-mobility group box) is a protein domain which is involved in DNA binding. The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding.
Research
1,601 papers- Mitochondrial HMG-Box Containing Proteins: From Biochemical Properties to the Roles in Human Diseases.Biomolecules · 2020
- HMG box containing transcription factors in lymphocyte differentiation.Seminars in immunology · 1998
- WD Repeat and HMG Box DNA Binding Protein 1: An Oncoprotein at the Hub of Tumorigenesis and a Novel Therapeutic Target.International journal of molecular sciences · 2023
- The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins.Cellular and molecular life sciences : CMLS · 2007
- The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways.Cellular and molecular life sciences : CMLS · 2019
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In molecular biology, the HMG-box (high-mobility group box) is a protein domain which is involved in DNA binding. The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding.
==Structure== The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).