HNF4A

Name

hepatocyte nuclear factor 4 alpha

Type

protein-coding

Position

44,355,439–44,432,845 (+)

Aliases

FRTS4, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21

Ensembl

ENSG00000101076

RefSeq RNA

NM_000457.6, NM_001030003.3, NM_001030004.3, NM_001258355.2, NM_001287182.2

RefSeq protein

NP_000448.3, NP_001025174.1, NP_001025175.1, NP_001245284.1, NP_001274111.1

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012].

via MyGene.info

Gene · Ensembl

hepatocyte nuclear factor 4 alpha

Symbol

HNF4A

Biotype

Protein coding

Organism

Homo sapiens

Location

20:44,355,439-44,432,845

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein HNF4A PDB 1m7w.png

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