honokiol
Sign in to saveHonokiol is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus Magnolia. It has been identified as one of the chemical compounds in some traditional Eastern herbal medicines along with magnolol, 4-O-methylhonokiol, and obovatol.
Chemical data
- Formula
- C18H18O2
- Molecular weight
- 266.3 g/mol
- IUPAC name
- 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- +266.131
Show 1 more fact
- P703
- Torreya nucifera
via Wikidata · CC0
Article
23 sectionsContents
- Biology
- Chemistry
- Structure
- Purification
- History
- Traditional medicine
- Western medical research
- Side effects and contraindications
- Pharmacology
- Antitumorigenic activities
- Neurotrophic activity
- Antithrombotic activity
- Anti-inflammatory activity
- Antioxidant activity
- Cytotoxicity inhibition
- GABA<sub>A</sub> modulation
- Ca<sup>2+</sup> inhibition
- Antiviral activity
- Metabolic activity
- Pharmacokinetics
- Delivery methods
- References
- External links
Honokiol is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus Magnolia. It has been identified as one of the chemical compounds in some traditional Eastern herbal medicines along with magnolol, 4-O-methylhonokiol, and obovatol.
Honokiol, a compound with a spicy odor extracted from various Magnolia species worldwide, including those native to the Southeastern United States and Mexico, can readily cross the blood-brain and cerebrospinal fluid barriers, making it a highly bioavailable and potentially effective therapeutic agent. Honokiol is a small, hydrophobic neolignan biphenol structurally similar to propofol that can be purified efficiently from its isomer magnolol using advanced chromatography techniques such as magnolol acetonide protection followed by flash chromatography or high-capacity high-speed countercurrent chromatography.