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GeneQ18027135· pop 6· linked from 813 articles

HOXA7

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Also known as ANTP, HOX1, HOX1.1, HOX1A, homeobox A7

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

Gene data

HOXA7
Name
homeobox A7
Type
protein-coding
Position
27,153,716–27,157,936 (−)
Aliases
ANTP, HOX1, HOX1.1, HOX1A
Ensembl
ENSG00000122592
RefSeq RNA
NM_006896.4, XM_054358068.1, XM_054358069.1, XM_054358070.1, XM_054358071.1
RefSeq protein
NP_008827.2, XP_054214043.1, XP_054214044.1, XP_054214045.1, XP_054214046.1

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008].

Gene Ontology

via MyGene.info

Gene · Ensembl

homeobox A7

Symbol
HOXA7
Biotype
Protein coding
Organism
Homo sapiens
Location
7:27,153,716-27,157,936
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections
Contents
  • See also
  • References
  • Further reading
  • External links

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.

Excerpted from Wikipedia’s “HOXA7” article, available under the CC BY-SA 4.0 licence.

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