Structure via PubChem · Public domain (PubChem)
هیدروکسی اوره
Sign in to saveAlso known as Droxia®, Hydrea®, SQ-1089, Hydroxycarbamidum, Hidroxicarbamida, Hydroxyurea, Hydroxycarbamide, N-Carbamoylhydroxylamine
Hydroxycarbamide, also known as hydroxyurea, is an antimetabolite medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. In sickle-cells disease it increases fetal hemoglobin and decreases the number of attacks. It is taken by mouth.
Key facts
- Drug.N
- 2
- Drug.O
- 2
- Drug.SMILES
- O=C(N)NO
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458281479
- Drug.image
- Hydroxyurea.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 140
- Drug.alt
- Structural formulas
- Drug.image2
- Hydroxyurea-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.USAN
- Hydroxyurea
- Drug.tradename
- Droxia, Hydrea, Siklos, others
- Drug.MedlinePlus
- a682004
- Drug.DailyMedID
- Hydroxyurea
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L01
via Wikipedia infobox
Chemical data
- Formula
- CH4N2O2
- Molecular weight
- 76.055 g/mol
- IUPAC name
- hydroxyurea
- SMILES
- C(=O)(N)NO
- InChIKey
- VSNHCAURESNICA-UHFFFAOYSA-N
- XLogP
- -1.8
- Polar surface area
- 75.4 Ų
- H-bond donors
- 3
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1967
- Admin. routes
- oral
- Indications
- leukemia, melanoma, essential thrombocythemia, polycythemia vera
via ChEMBL · EBI
Research
14,633 papers- Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
- Hydroxyurea (hydroxycarbamide) for sickle cell disease.The Cochrane database of systematic reviews · 2022
- Hydroxyurea (hydroxycarbamide) for transfusion-dependent β-thalassaemia.The Cochrane database of systematic reviews · 2019
- Guidelines for the use of hydroxycarbamide in children and adults with sickle cell disease: A British Society for Haematology Guideline.British journal of haematology · 2018
- Hydroxycarbamide: clinical aspects.Comptes rendus biologies · 2013
via PubMed
Wikidata facts
- Mass
- 76.027
- Has use
- medication
Show 6 more facts
- medical condition treated
- acute myeloid leukemia
- chemical formula
- CH₄N₂O₂
- World Health Organisation international non-proprietary name
- hydroxycarbamide
- canonical SMILES
- C(=O)(N)NO
- Commons category
- Hydroxyurea
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0