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Epomediol
Sign in to saveAlso known as Clesidren, 2,6-Dihydroxycineol
Epomediol (trade name Clesidren) is a synthetic terpenoid with choleretic effects. It has been used in the symptomatic treatment of itching due to intrahepatic cholestasis of pregnancy.
Chemical data
- Formula
- C10H18O3
- Molecular weight
- 186.25 g/mol
- IUPAC name
- 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane-6,7-diol
- SMILES
- CC1(C2CC(C(O1)(C(C2)O)C)O)C
- InChIKey
- JSNQSLSBBZFGBM-UHFFFAOYSA-N
- XLogP
- 0.2
- Polar surface area
- 49.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
32 papers- Effects of epomediol on ethinyloestradiol-induced changes in glutathione homeostasis in the rat.Pharmacology & toxicology · 2002
- Effect of epomediol on ethinyloestradiol-induced changes in bile acid and cholesterol metabolism in rats.Clinical and experimental pharmacology & physiology · 2001
- Effect of the terpenic compound epomediol on biliary secretion and bile composition in the rat.Journal of hepatology · 1992
- [Symptomatic effect of epomediol in patients with cholestasis of pregnancy].Revista medica de Chile · 1992
- Effect of epomediol on taurocholate uptake in hepatocytes isolated from normal rats or rats with ethinyloestradiol-induced cholestasis.Pharmacology & toxicology · 1993
via PubMed
Wikidata facts
- Mass
- 186.125594
Show 3 more facts
- chemical formula
- C₁₀H₁₈O₃
- canonical SMILES
- CC1(C2CC(C(O1)(C(C2)O)C)O)C
- Commons category
- Epomediol
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Epomediol (trade name Clesidren) is a synthetic terpenoid with choleretic effects. It has been used in the symptomatic treatment of itching due to intrahepatic cholestasis of pregnancy.
==References==
Excerpted from Wikipedia’s “Epomediol” article, available under the CC BY-SA 4.0 licence.